Expanding Antineoplastic Drugs Surface Monitoring Profiles: Enhancing of Zwitterionic Hydrophilic Interaction Methods

Antineoplastic drugs are a wide and heterogeneous group of substances that, as universally known, can cause highly severe toxic effects to whoever is exposed. From an occupational safety point view, surface contaminations inside preparation administration units growing issue therefore require the development implementation sensible fast monitoring methods. The unlikelihood unique all-embracing chromatography, able correctly retain separate each analyte led need create orthogonal normal phase analysis, which might be fill gaps in more common reversed-phase ones. An existing hydrophilic interaction method has thus been expanded 6 other applied real samples after evaluation its performances. experimental data were then used evaluate possibility estimating reliable relationships between chromatographic retention chemical-structural features under analysis.